Кардіопротекторна дія індукторів синтезу білка KLOTHO за умов гострого експериментального інфаркту міокарда
نویسندگان
چکیده
منابع مشابه
Klotho
The Klotho gene codes for a type-i membrane protein that exists in two forms—as a transmembrane protein and as a secreted protein. Particularly the secreted form of Klotho suppresses oxidative stress and growth factor signaling and regulates ion channels and transporters. it was reported that Klotho overexpression suppresses insulin/iGF-1 signaling. This signaling pathway was indicated as a cen...
متن کاملPhosphate and Klotho
Klotho is a putative aging suppressor gene encoding a single-pass transmembrane co-receptor that makes the fibroblast growth factor (FGF) receptor specific for FGF-23. In addition to multiple endocrine organs, Klotho is expressed in kidney distal convoluted tubules and parathyroid cells, mediating the role of FGF-23 in bone-kidney-parathyroid control of phosphate and calcium. Klotho(-/-)mice di...
متن کاملGrowth hormone and Klotho.
Acromegaly is characterized by excessively high GH and IGF1 levels. Recent data suggest that soluble Klotho (sKlotho) is also elevated in patients with active acromegaly. sKlotho decreases towards normal following removal of the GH-producing pituitary adenoma. The Klotho gene was identified in mice following its accidental disruption by ectopic DNA. It is an ageing suppressor gene of restricted...
متن کاملKlotho and Renal Fibrosis
Implication for health policy/practice/research/medical education: Klotho is a newly discovered protein with pleotropic effects and have affected different fields of renal medicine from translational research to clinical nephrology. Here we want to summarize some new scopes in the field of renal fibrosis and Klotho with this hope that in future it could be implemented as a new therapeutic strat...
متن کاملKlotho and the Aging Process
The klotho gene was originally identified as a putative age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted. The gene was named after a Greek goddess Klotho who spun the thread of life. Since then, various functional aspects of the klotho gene have been investigated, leading to the identi...
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ژورنال
عنوان ژورنال: Фармакологія та лікарська токсикологія
سال: 2020
ISSN: 2524-2563,2227-7943
DOI: 10.33250/14.05.337